Previous captain Jamie George has been ruled out of Englands first Six Nations; The England squad has been hit by five injuries including Georges after the weekends club matches and new players have been called up;

Hooker George, who has been replaced by Maro Itoje as captain, suffered a hamstring injury playing for Saracens in the Champions Cup and is among a group of five forced to withdraw from a pre-tournament training camp in Girona.

England head coach Steve Borthwick has been forced to call up five players after his Six Nations squad was rocked by injury on a damaging weekend of club rugby.

First-choice scrum-half Alex Mitchell, who missed the autumn Tests with a neck injury, could also miss the game with a knee problem he picked up against Munster on Friday

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.