The bendamustine molecule is composed of 3 structural elements: a mechlorethamine (nitrogen mustard) group, a benzimidazole ring, and a butyric acid side chain (Figure 1). The mechlorethamine ...

Bendamustine is provided in a single-use vial containing 100 mg of lyophilized bendamustine hydrochloride powder, which should be reconstituted with 20 mL of sterile water to yield a clear, colorless ...

Phase II Study of Nelarabine (compound 506U78) in Children and Young Adults With Refractory T-Cell Malignancies: A Report From the Children’s Oncology Group A total of 245 courses (median, four ...

A review published in Transfusion Medicine Reviews discussed the 2 therapeutic approaches and their pros and cons for treating cold agglutinin disease (CAD). CAD is a rare hemolytic disorder that ...

On Friday, Cephalon Inc. announced that the FDA approved bendamustine hydrochloride injection (Treanda) for use in patients with relapsed indolent non-Hodgkin’s lymphoma. The drug is approved for ...

Considering Bone Marrow Blasts From Nonerythroid Cellularity Improves the Prognostic Evaluation of Myelodysplastic Syndromes In total, 59 patients were enrolled. After four cycles of therapy, 43 ...

Findings from the phase 3 SEQUOIA trial favored zanubrutinib over bendamustine plus rituximab in most biomarker-based subgroups of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic ...

“Moving forward, (bendamustine and Rituxan) will likely become a common backbone for the incorporation of other cytotoxic or novel agents in an attempt to further improve outcomes while maintaining an ...

The appraisal committee considered evidence submitted by Roche, a review of this submission by the evidence review group (ERG), and the technical report developed through engagement with stakeholders.

The Appraisal Committee reviewed the data available on the clinical and cost effectiveness of bendamustine, having considered evidence on the nature of chronic lymphocytic leukaemia in patients for ...