Chaperones support protein folding in different cellular compartments and some chaperones associate with ribosomes to help fold newly synthesized proteins. Two studies by Koplin et al. and Albanèse et ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

As the body ages, brown adipose tissue activity decreases, fewer calories are burned, and this can contribute to obesity and certain chronic cardiovascular diseases that worsen with age. A study led ...

Like a parent of teenagers at a party, Mother Nature depends on chaperones to keep one of her charges, the immune system, in line so that it doesn't mistakenly attack normal cells, tissues and organs ...

A recent study from CU Boulder researchers shows that cells must actively work to keep sticky molecules, known as ribonucleic acid (RNA), apart, or they may form large assemblies that could cause ...

Figure 1: The molecular chaperone network. Client proteins rely on sequential interactions with chaperones, cochaperones, and chaperonins to fold into an active, native, state. Thus, functional levels ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

There are around 20,000 human genes that encode for protein, which carry out many of the essential functions of cells. Active genes are transcribed into molecules known as messenger RNAs (mRNAs), ...