San Francisco 49ers running back Christian McCaffrey is on pace for another historic season, potentially etching his name alongside some of the NFL's all-time greats.

San Francisco 49ers head coach Kyle Shanahan discussed the team's injury status, highlighted the offensive momentum led by QB Mac Jones and RB Christian McCaffrey, and shared how the 49ers are prepari

Christian McCaffrey speaks out on the San Francisco 49ers’ mounting injury challenges after losing to the Houston Texans.

San Francisco 49ers TE George Kittle came forward to defend his friend and teammate, Christian McCaffrey, amid the backlash for his underwhelming performance this season.

SANTA CLARA — After a frustrating, injury-plagued 2024 NFL season, Christian McCaffrey is ready to move forward -- both healthy and happy. The All-Pro ball carrier spoke to local Bay Area media Tuesday and shared an update on his physical health.

Christian McCaffrey and the San Francisco 49ers hope to get back on track running the ball against the New York Giants and their 30th-ranked rush defense.

The Rams chase redemption and first place in the NFC West as they face the battered 49ers in a high-stakes Week 10 rematch.

According to FanDuel Sportsbook, Indianapolis Colts running back Jonathan Taylor is the clear favorite (-135) to win NFL Offensive Player of the Year honors this season.

One day after popping up on the injury report on Thursday, San Francisco 49ers running back Christian McCaffrey has spoken about his issue. McCaffrey was listed as limited on Thursday's injury report with a calf injury, which is especially concerning given ...

At a couple of positions where the 49ers could least afford it, there are some new injuries. Perhaps, precautionary.