The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

New research shows that the nuclease domain of the E. coli RecBCD helicase plays a key role in regulating DNA binding and the extent of base pair melting during double-strand break repair. Deleting ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

A diagram of the DRT3 system, showing Drt3a in yellow and Drt3b in blue. (Hyunbin Lee) Scientists have just discovered an ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

Delve into the field of PARP inhibitors, a class that has gained traction in ovarian, breast, and prostate cancers.

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...