A winter storm is hitting the Midwest with snow and wintry conditions, causing travel issues for many who were looking to get home following Thanksgiving. At least 450 flights had been canceled around the United States as of 7 a.m. ET, with the biggest impacts at Chicago's O’Hare Airport, according to FlightAware, a flight-data tracker.

Des Moines Airport has recorded nearly 4 inches of snow on Saturday as a winter storm dumps snow on the Midwest this weekend. FOX Weather Storm Specialist Mike Seidel reports from downtown Des Moines where heavy snow continues to fall and coat roads.

The winter storm warning runs from 6 a.m. Nov. 29 until 6 a.m. Nov. 30, according to the National Weather Service.

Up to a foot of snow is expected across some areas of the Lower Peninsula with a storm system that starts marching across the state around noon on Saturday.

"Starting during the mid-morning hours tomorrow, around 9 a.m. to 10 a.m., we're going to be expecting some pretty significant impacts to the Indianapolis area, especially to the north of us," said Andrew White,

A winter storm brought snowfall to parts of northern Wisconsin overnight into Wednesday, November 26, with heavy snowfall rates expected to continue until Wednesday night.Footage taken by Brooke Trettin shows conditions south of Ashland,

Strong winds gusting to 50 mph combined with heavy snow are creating whiteout conditions and making travel extremely hazardous.