Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors ...
Inflammatory pathways involving microglia, astrocytes, and cytokine signaling are widely implicated in disorders including Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, and ...
When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...
Tyrosine kinase 2 (TYK2), expressed in astrocytes and microglia, is involved in the activation of pathways triggered by proinflammatory cytokines, such as IL-23, IL-12 and type I interferons (IFNs), ...
For these reasons, manipulation of proinflammatory cytokine levels is a tempting therapeutic target. Etanercept is a dimeric fusion protein consisting of the extracellular ligand-binding portion of ...
A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering human ...
Morning Overview on MSN
Scripps just found a hidden switch inside Alzheimer brains called STING — and shutting it off stopped the runaway immune response that keeps neurons burning
Scientists at Scripps Research have identified a specific chemical modification on the STING protein that appears to lock ...
In a recent study published in the journal Nature, a group of researchers investigated how aging alters neuronal protein degradation, aggregation, and transfer to microglia, with a focus on synaptic ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results