Xenotransplantation models represent powerful tools for the investigation of healthy and malignant human hematopoiesis. However, current models do not fully mimic the components of the human bone ...

In vivo models of human immunity in human tumor-bearing mice are frequently used to study mechanisms of targeted immunotherapies, safety, and efficacy. In a recent webinar Jenny Rowe, PhD, Scientist ...

Why do 80 to 90% of people infected with COVID-19 experience only mild cases while 10 to 20% face more severe or life-threatening symptoms? Researchers in the lab of Yale’s Richard Flavell decided to ...

Mice are commonly used as models of human disease, helping scientists to understand the workings of complex pathologies and develop safe and efficacious drugs. It is now possible to create a range of ...

For the first time, scientists have successfully created a type of mouse with a 100% functional human immune system and human-like gut microbiome. This 'humanized' mouse takes the guesswork out of ...

Researchers have created a functional 'humanized' liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic ...

A severe organ shortage plagues the progress of organ transplantation. One solution may be to generate human organs in other large mammals, however, that process is challenging. Now, researchers have ...

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created ...

Animal research models are only as effective as their ability to simulate human disease. Depending on the condition being studied, researchers were at one time limited to available species that could ...

Currently developed cancer immunotherapies modify the interaction of cancer cells and the immune system, making drug testing targeting human cancer outside of clinical trials difficult. Kobe ...