Introduction to Mendelian randomization, the problems with using traditional observational studies to investigate causality, and Randomized controlled trials as the gold standard for causal research.

Mendelian randomization is a method for causal inference that leverages the random inheritance of alleles as instrumental variables to estimate the causal effects of exposures on outcomes 1,2,3,4 (Box ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal ...

Increasing evidence indicates a role for inflammation, the tissue response to potentially harmful stimuli, in the pathogenesis of mental health disorders, particularly depression 1,2. Even though, ...