A preclinical study led by a neuroscientist shows that dysregulated kappa-opioid receptors (KORs) in the brain's medial prefrontal cortex region (part of the frontal lobe) contribute to working memory ...

Opioids remain the most potent and effective pain relievers in medicine, but they're also among the most addictive drugs that can halt a person's ability to breathe during an overdose - which can be ...

Opioids remain the most potent and effective pain relievers in medicine, but they’re also among the most addictive drugs that can halt a person’s ability to breathe during an overdose — which can be ...

Scientists have identified a potential pathway to pain relief that neither triggers addiction nor causes hallucinations. Strategies to treat pain without triggering dangerous side effects such as ...

While opioids like fentanyl and oxycodone are among the most powerful painkillers known to modern medicine, they are also extremely addictive and therefore, increasingly hard to get – even for those ...

Kappa-opioid antagonists offer a potential treatment to help alcohol-dependent patients cut back or quit drinking, University of South Florida preclinical study suggests “People with severe alcohol ...