Background: The traditional emphasis on developing high specificity pharmaceuticals ("magic bullets") for the treatment of Neurological and Psychiatric disorders is being challenged by emerging ...

Ionotropic glutamate receptors are tetrameric protein complexes that transduce chemical signals carried by neurotransmitter molecules into electrical impulses propagated in the postsynaptic neuron.

Signalling processes in organisms are governed by specific extracellular and intracellular interactions and involve hundreds of different functionally highly versatile receptors situated in cell ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, ...

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more ...

Drug promiscuity can also be evaluated from the reverse perspective, focusing instead on the ability of a single therapeutic agent to interact with multiple protein targets. The most comprehensive ...