Description Microbial metabolism represents one of the most chemically diverse and functionally complex systems in nature. Despite decades of research, a ...

The transformation of healthy cells into invasive colorectal tumors is an extraordinarily complex process involving numerous molecular mechanisms, according to cancer biologists in China who have ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Center have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Enzymes are amazing catalysts. These proteins are made of nothing more than a handful of Earth-abundant elements, and they promote a vast array of reactions, convert chemical energy to physical motion ...

Enzyme 'atlas' helps researchers decipher cellular pathways Biologists have mapped out more than 300 protein kinases and their targets, which they hope could yield new leads for cancer drugs ...

Terpenoids represent the most diverse class of specialized metabolites in plants, yet they originate from just two simple precursors—isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) ...

Their overview highlights innovative methods based on B-factor analysis, ancestral sequence reconstruction (ASR), and machine learning (ML), providing tools to design enzymes that withstand high ...