Several classes of compounds are either unreactive or give very poor yields in Friedel-Crafts reactions. These limitations ...

The intermediate σ complex presumed, but not seen, to be involved in nucleophilic aromatic substitution reactions has now been observed experimentally The transition state of a nucleophilic aromatic ...

Understanding the delicate balance between nucleophilicity and electrophilicity is fundamental to rationalising reaction mechanisms in organic chemistry. Nucleophilic reactivity describes a molecule’s ...

In undergraduate organic chemistry courses, nucleophilic substitution reactions are often carried out as an experiment. Reactions that occur at saturated carbons are chiefly categorized as S N 1 or S ...

A new halide addition reaction represents a means by which halides can be incorporated into biomolecules. The reaction was discovered by chemistry professors Charles L. Perrin and Joseph M. O'Connor ...

Joseph F. Bunnett, 93, died on May 23, 2015, in Santa Cruz, Calif. “Joe Bunnett was an internationally renowned physical organic chemist best known for his seminal work on the mechanisms of ...