Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Muse Treatment Alcohol & Drug Rehab Los Angeles has published a new educational resource that explains how opioid receptors ...

Neuropeptide FF (NPFF) is an endogenous peptide that plays a critical role in modulating opioid receptor function. Its dual capacity to influence both opioid-induced analgesia and tolerance has ...

University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and ...

The opioid-modulating peptides NPFF and RFRP-3 selectively activate NPFFR1 and NPFFR2 through a message–address binding mechanism, where conserved motifs at the peptides’ C-termini engage the ...

A cross-country research team has identified a promising approach to improving the life-saving function of naloxone (Narcan), a drug used to reverse opioid overdose. The researchers published their ...

Rutgers has granted Tonix Pharmaceutical exclusive worldwide rights to develop and commercialize a novel class of compounds ...

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

July 3 (UPI) --U.S. researchers said Wednesday that they have identified a new drug that could make inroads on the devastation caused by opioids -- by supercharging naloxone, branded as Narcan, the ...