Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death. Although the causal link between protein aggregates and ...

A cellular recycling system called CMA was found to be impaired in ALS motor neurons. Reduced CMA activity was linked to TDP-43 protein clumps, a hallmark of most ALS cases. Boosting CMA may be a ...

Misfolding occurs when a protein adopts a conformation which differs from the native one. The researchers, funded by the National Institute of Neurological Disorders and Stroke, have developed an ...

Misshapen proteins cause a mess of trouble—particularly in neurodegenerative diseases. But a new study suggests it's possible ...

Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Dementia affects over 57 million people worldwide, a number expected to nearly double in the next 20 years. This permanent ...

Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation ...

TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of ...

Moreover, a protein called TDP-43 has been found to abnormally accumulate in the neurons affected by ALS, leading to the degeneration of these neurons and motor dysfunction. In patients with ALS, the ...

There is a strong link between the loss of TAR DNA-binding protein 43 (TDP-43) function and the development of frontotemporal dementia (FTD) pathology, a neurodegenerative disorder where ...