There are five major storylines to know heading into the Tennessee Titans vs. San Francisco 49ers Week 15 matchup.

The Tennessee Titans remain on the road in Week 15 when they head to Santa Clara, California, to face the San Francisco 49ers this Sunday. This is a nightmare matchup for the Titans, and it will be ...

The Tennessee Titans lost to the San Francisco 49ers, 37-24, in Week 15 action, and here's how fans reacted on social media ...

Here's a look at the studs and duds (and those in between) from the Tennessee Titans' 37-24 loss to the San Francisco 49ers ...

SANTA CLARA, Calif. (AP) — Brock Purdy threw three touchdown passes and the San Francisco 49ers started the stretch run of ...

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to ...

NFL Insider Tom Pelissero breaks down the playoff clinching scenarios around the NFL in Week 16. San Francisco 49ers have a shot to clinch on "Monday Night Football" with a win. NFL Network's "Good ...

The Tennessee Titans (2-11) will face the San Francisco 49ers (9-4) at Levi's Stadium in Santa Clara, California, this Sunday at 3:25 p.m. CST. Opening the week, the Titans were listed as 12.5-point ...