CAG and CTG (CWG) trinucleotide repeat expansions cause various neurological diseases, which can be classified as polyglutamate (polyQ) disorders (such as Huntington disease (HD)) with abnormal CAG ...
Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more than 40 severe neurological ...
A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression. Research has identified a critical DNA repair ...
Repeat expansion disorders, which are responsible for more than 40 neurological diseases, may be more common than clinical data would suggest. Epidemiological studies had estimated that REDs affect ...
Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their ...
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