Feb. 16, 2021 — Researchers may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing ...

Using precise molecular techniques, including single-cell RNA sequencing, the team showed that this process is mediated in part by the effects of CD4 T cells on CD8 T cells – another subset of ...

T cells, another important white blood cell of the immune system, also play a part, and specifically CD4+, or helper T cells, that can initiate immune responses.

Moreover, the Aldridge Lab used time-lapse, single-cell imaging to discover that the two poles of Mycobacterium tuberculosis grow at different rates. This means that one end will end up growing faster ...

The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the ...

The body's first line of defense against tuberculosis (TB) involves immune cells that suppress lung inflammation instead of activating it, report University of Pittsburgh and the Ragon Institute ...

More information: Nezar Mehanna et al, CD8α marks a Mycobacterium tuberculosis-reactive human NK cell population with high activation potential, Scientific Reports (2025). DOI: 10.1038/s41598-025 ...

“Flow cytometry and single-cell RNA sequencing revealed polyfunctional cytotoxic CD8 + lymphocytes in control granulomas, while CD8-depleted animals were unexpectedly enriched in CD4 and γδ T ...

Current tuberculosis infection tests struggle to detect the disease in those with HIV. A common co-infection, HIV can hide TB ...

For example, whereas M. tuberculosis resides largely within vacuoles in the infected cell, M. marinum can escape into the cytoplasm and probably takes advantage of efficient mechanisms of cell-to ...

Tuberculosis is a dramatic problem worldwide, with 1.7 billion people (one third of the world's population) infected with Mycobacterium tuberculosis.1 In hematopoietic stem cell transplant (SCT ...