The San Francisco 49ers didn’t list Yetur Gross-Matos on Thursday’s injury report, which was a good sign that the defensive lineman, who has been out since Week 15, would return in Week 15. Gross-Matos practiced on Friday and is expected to be activated from the Injured Reserve on Saturday.

It wouldn't be a normal injury report for the 49ers if they didn't have some players ruled out for game day.

While it's unclear if San Francisco 49ers wide receiver Brandon Aiyuk will play another snap for the team, quarterback Brock Purdy hopes he does.

The San Francisco 49ers have shared an injury update that could completely change the balance of power in the NFC.

Coming off the bye week, the San Francisco 49ers find themselves in an enviable position. They are rested, getting healthier, and eyeing not just the playoffs but potentially the NFC’s No. 1 seed.

The San Francisco 49ers avoided a disaster with their superstar running back on their Week 15 injury report.

San Francisco 49ers quarterback Brock Purdy has a 4–1 record as a starter this year, despite battling a turf toe injury he suffered at the very start of the season.