In this video, Aruna Padmanabhan, MD, discusses the evaluation of PI3K inhibitor combinations as first-line treatment for patients with metastatic breast cancer.

Insmed's promising drug pipeline includes Brensocatib and Arikayce. See why INSM stock is a strong pick with multi-billion ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Each cell layer was isolated as described above; proteins were extracted from cells using RIPA lysis buffer (50 mM Tris-HCl, 150 mM NaCl, 0.25% Sodium Deoxycholate, 1 mM EDTA, 1% Nonidet P-40 with ...

including a detailed assessment of the proteinase-antiproteinase balance within the lung of cystic fibrosis patients with normal and variant α 1-AT alleles. This is an important area of research in ...

Cell cycle re-entry of senescent breast cancer cells after CDK4/6 inhibition (CDK4/6i) constitutes a major source of disease ...

GLP-1 receptor agonists conferred greater HbA1c reductions in older adults than younger adults. Older adults had a lower risk for major adverse CV events than younger adults with SGLT2 inhibitors.

Table 1, which samples currently approved protease inhibitors based on protease types, is notable for its brevity and the absence of new targets that have not already been known for decades (see Ref.

TB Alliance has disclosed new ATP-dependent Clp protease ClpP1P2 complex (Mycobacterium tuberculosis) inhibitors reported to be useful for the treatment of tuberculosis.