Once thought to have originated in cows and spread through dust, the surprising evolutionary story of tuberculosis reveals ...

Bacille Calmette-Guérin revaccination shows no efficacy in preventing sustained Mycobacterium tuberculosis infection compared with placebo in adolescents in a phase 2b study.

Feb. 16, 2021 — Researchers may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing ...

Moreover, the Aldridge Lab used time-lapse, single-cell imaging to discover that the two poles of Mycobacterium tuberculosis grow at different rates. This means that one end will end up growing faster ...

Current tuberculosis infection tests struggle to detect the disease in those with HIV. A common co-infection, HIV can hide TB ...

More information: Nezar Mehanna et al, CD8α marks a Mycobacterium tuberculosis-reactive human NK cell population with high activation potential, Scientific Reports (2025). DOI: 10.1038/s41598-025 ...

T cells, another important white blood cell of the immune system, also play a part, and specifically CD4+, or helper T cells, that can initiate immune responses.

The body's first line of defense against tuberculosis (TB) involves immune cells that suppress lung inflammation instead of activating it, report University of Pittsburgh and the Ragon Institute ...

“Flow cytometry and single-cell RNA sequencing revealed polyfunctional cytotoxic CD8 + lymphocytes in control granulomas, while CD8-depleted animals were unexpectedly enriched in CD4 and γδ T ...

Legislation that aims to prevent preventable deaths from tuberculosis infection is one step closer to becoming law.

Tuberculosis is a dramatic problem worldwide, with 1.7 billion people (one third of the world's population) infected with Mycobacterium tuberculosis.1 In hematopoietic stem cell transplant (SCT ...

A study utilizing alveolar macrophage-like (AML) cells revealed that tumor necrosis factor (TNF) is critical for fighting tuberculosis but not other infections. The findings challenge existing beliefs ...