Spina bifida and anencephaly are neural tube defects caused by failure of embryonic neural tube closure. Successful closure requires apicobasal elongation and apical constriction of neuroepithelial ...

Identification of a nitric oxide-regulated transitional state of Müller glia reveals a key mechanism enabling neuronal regeneration in the injured vertebrate retina.

High-profile news coverage that eLife papers generated in October 2025, including NPR, One Earth and Neuroscience News.

The authors present convincing data to validate abscisic acid-induced dimerisation to induce a synthetic spindle assembly checkpoint (SAC) arrest that will be of particular importance to analyse ...

Researchers have mapped the cellular diversity of the eye’s fluid drainage tissue, uncovering a cell subtype that may contribute to glaucoma progression and respond to vitamin B3 treatment.

Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

The ReproSci project retrospectively analyzed the reproducibility of 1006 claims from 400 papers published between 1959 and 2011 in the field of Drosophila immunity. This project attempts to provide a ...

This important study builds on previous work from the same authors to present a conceptually distinct workflow for cryo-EM reconstruction that uses 2D template matching to enable high-resolution ...

Proteomics experiments on Drosophila reveal sex-specific effects in aging, and an important role for a protein called DIP-β.

Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.