In this video, Aruna Padmanabhan, MD, discusses the evaluation of PI3K inhibitor combinations as first-line treatment for patients with metastatic breast cancer.

Insmed's promising drug pipeline includes Brensocatib and Arikayce. See why INSM stock is a strong pick with multi-billion ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Approximately 75% of BCs are estrogen receptor alpha positive (ERα+) and responsive to ovarian ... such as ICI/fulvestrant) and aromatase inhibitors (AIs) (Patel and Bihani, 2018). Despite ET efficacy ...

1 2 Destruction of the articular bone has been demonstrated ... buffer supplemented with phosphatase and protease inhibitors (Roche). Western blotting (WB) was performed as described.29 Primary ...

including a detailed assessment of the proteinase-antiproteinase balance within the lung of cystic fibrosis patients with normal and variant α 1-AT alleles. This is an important area of research in ...

2010;5(1):101-115. Despite animal and human studies ... Psoriasis Area and Severity Index. TNF inhibitors can induce remission and prevent both clinical and radiological disease progression ...

Shionogi & Co. Ltd. won a $375 million project agreement from the Rapid Response Partnership Vehicle to develop its 3CL protease inhibitor, S-892216, as a long-acting injectable for COVID-19 ...

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...