β -lactamase inhibitors - SlideServe
β -lactamase inhibitors - SlideServe
Jul 20, 2014
slideserve.com
AmpC β-lactamases are class C enzymes under the Ambler classification scheme, containing serine residues at their active site for catalysis. Mechanisms of AmpC β-lactamase resistance can be divided into 3 categories: (1) inducible resistance via chromosomally encoded ampC genes (eg, Enterobacter cloacae, Serratia marcescens, Citrobacter freundii, Pseudomonas aeruginosa, etc.), (2) noninducible chromosomal resistance due to promoter and/or attenuator mutations (eg, Escherichia coli, Shigella spec
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